Table 1 Characteristics of participants in dataset 1
From: Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease
Characteristic | Total sample (n = 40) | Controls (n = 20) | AD (n =20) | P value |
|---|---|---|---|---|
Age, mean (SD) | 67.5 (5.4) | 66.8 (5.8) | 68.2 (5.0) | 0.43 |
Education year, mean (SD) | 9.1 (2.6) | 9.9 (3.0) | 8.4 (1.9) | 0.07 |
Women, no. (%) | 20 (50.0) | 10 (50.0) | 10 (50.0) | 1.00 |
APOE ε4 positive (%) | 12 (30.0) | 4 (20.0) | 8 (40.0) * | 0.03 |
MMSE score (SD) | 23.9 (5.2) | 28.9 (0.6) | 19.0 (1.8) * | < 0.001 |
Aβ42 (pg/ml), mean (SD) | 565.3 (250) | 762.1 (175.5) | 368.5 (126.4) * | < 0.001 |
P-tau181 (pg/ml), mean (SD) | 86.2 (53.7) | 58.6 (26.4) | 113.8 (60.1) * | 0.001 |
P-tau181/Aβ42, mean (SD) | 0.20 (0.2) | 0.08 (0.03) | 0.32 (0.14) * | < 0.001 |
T-tau (pg/ml), mean (SD) | 465.8 (185.8) | 335.2 (89.3) | 596.4 (179.0) * | < 0.001 |