Fig. 8

Concentration of Aβ in the plasma of heterozygote tg-ArcSwe mice following treatment with therapeutic doses of 30 nmol/kg body weight of sNEP-scFc-scFv8D3 or muNEP-scFc-scFv8D3, using scFc-scFv8D3 as the negative control. Significantly lower concentrations were detected of Aβ with free N and C-terminals (monomers and some of the aggregates) (A) and soluble aggregates with the N-terminal free (B) but not of Aβ detected with the arctic-specific antibody (middle region) and a N-terminal antibody (C). Since no difference was detected for monomers (D), or more specifically Aβ42 monomers, it seems like the difference is in the aggregates and possibly in the aggregates with the N- and C-terminal free. No difference was neither detected in murine Aβ. One-way ANOVA with Bonferroni’s multiple comparison test was applied (n = 3–4) (p > 0.05 = ns; p ≤ 0.05 = *; p ≤ 0.01 = **; p ≤ 0.001 = ***)