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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Fig. 3

ELISA experiments displaying binding of the recombinant proteins to mouse TfR and Aβ. A Indirect ELISA demonstrating similar binding to mouse TfR among the recombinant proteins using RmAb158-scFv8D3 as the positive control. B, C Sandwich ELISA displaying similar binding of sNEP-scFc-scFv8D3 and muNEP-scFc-scFv8D3 scFv8D3 to Aβ1-40 monomers (B) and Aβ1-42 soluble aggregates (C). scFc-scFv8D3 that lacks Aβ biding domain displayed no binding to Aβ. Results presented as mean ± SD (n = 2). Data generated from two repetitive experiments

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Alzheimer's Research & Therapy

ISSN: 1758-9193