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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer’s Disease (EPAD) cohort

Fig. 2

Boxplot showing the mean adjusted volumes of right and left entorhinal (up) and right and left amygdala volumes (down) in non-APOE4 versus APOE4 carriers, stratified according to HRT use. Pairwise comparison within each genotype group was carried out on the estimated marginal mean (within the MANCOVA model), after adjustment for age, years of education, marital status, handedness, and CDR. Volumes were adjusted to the whole brain volume: Statistical results in the upper left corner of the four brain regions show P values of APOE genotype, HRT, and APOE*HRT for each region using the MANCOVA model. Non-APOE4 n= 641 (no-HRT n=591, HRT n= 50), APOE4 n= 375 (no-HRT n=346, HRT n= 29)

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