ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease

Ko, Yi-An; Billheimer, Jeffrey T.; Lyssenko, Nicholas N.; Kueider-Paisley, Alexandra; Wolk, David A.; Arnold, Steven E.; Leung, Yuk Yee; Shaw, Leslie M.; Trojanowski, John Q.; Kaddurah-Daouk, Rima F.; Kling, Mitchel A.; Rader, Daniel J.

doi:10.1186/s13195-022-01119-z

Alzheimer's Research & Therapy

Table 3 Results from multivariable linear regression adjusting for age, sex, and race

From: ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease

				95% CI for USC B
Predictor	Dependent variable	USC B	Beta	Lower bound	Upper bound	P	R²	R² adjusted
CEC—N9	Aβ_1-42(pg/mL)	27.915	0.0935	− 35.5	91.330	0.385	0.03	− 0.029
CEC—SH-SY5Y	Aβ_1-42(pg/mL)	39.792	0.237	5.71	73.870	0.0226 *	0.07216	0.01649
ApoA-I (ng/mL)	Aβ_1-42(pg/mL)	1.97E−05	0.0629	− 4.67E−05	8.61E−05	0.5578	0.02574	− 0.03272
ApoE (ng/mL)	Aβ_1-42(pg/mL)	0.0193	0.421	0.01	0.03	2.5e−05 ***	0.1822	0.1331
ApoJ (ng/mL)	Aβ_1-42(pg/mL)	0.00439	0.202	− 4.04E−04	0.010	0.0722	0.0536	− 0.003175
CEC—N9	Ttau (pg/mL)	− 3.209	− 0.0181	− 37.171	30.753	0.852	0.206	0.158
CEC—SH-SY5Y	Ttau (pg/mL)	0.535	0.00536	− 18.134	19.204	0.955	0.210	0.163
ApoA-I (ng/mL)	Ttau (pg/mL)	3.48E−05	0.187	− 4.35E−09	6.96E−05	0.0500	0.240	0.195
ApoE (ng/mL)	Ttau (pg/mL)	− 1.28	− 0.0468	− 6.34	3.78	0.617	0.212	0.165
ApoJ (ng/mL)	Ttau (pg/mL)	0.00114	0.0881	− 1.45E−03	0.004	0.386	0.2161	0.1691
CEC—N9	Ptau (pg/mL)	− 6.827	− 0.0862	− 22.451	8.797	0.388	0.163	0.113
CEC—SH-SY5Y	Ptau (pg/mL)	− 1.047	− 0.0234	− 9.695	7.6	0.811	0.157	0.106
ApoA-I (ng/mL)	Ptau (pg/mL)	8.63E−06	0.104	− 7.72E−06	2.50E−05	0.297	0.1655	0.1154
ApoE (ng/mL)	Ptau (pg/mL)	− 0.00253	− 0.00	− 4.82E−03	− 2.37E−04	0.0309 *	0.1949	0.1466
ApoJ (ng/mL)	Ptau (pg/mL)	− 0.0008385	− 0.145	− 1.45E−03	3.73E−03	0.166	0.172	0.123
CEC—N9	Ptau/Aβ_1-42ratio	− 0.0944	− 0.180	− 0.201	0.013	0.08298	0.1182	0.06417
CEC—SH-SY5Y	Ptau/Aβ_1-42ratio	− 0.0413	− 0.139	− 0.101	0.018	0.170	0.107	0.0532
ApoA-I (ng/mL)	Ptau/Aβ_1-42ratio	6.96E−08	0.126	− 4.35E−08	1.83E− 07	0.225	0.104	0.0493
ApoE (ng/mL)	Ptau/Aβ_1-42ratio	− 2.39E−05	− 0.295	− 3.94E−05	− 8.38E−06	0.00288 **	0.169	0.118
ApoJ (ng/mL)	Ptau/Aβ_1-42ratio	− 5.49E−06	− 0.142	− 1.38E−05	2.79E−06	0.191	0.106	0.0516

USC unstandardized regression coefficient, SE standard errors of the regression coefficients, Sig two-sided observed significance levels (P) for the t statistics. Significant P-values: *P < 0.05;**P < 0.01;***P < 0.001

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