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Table 2 One-way ANOVA test of CSF cholesterol efflux capacity, lipids, lipoproteins, and known AD biomarkers

From: ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer’s disease

 

CN (n = 50)

MCI (n = 18)

AD (n = 40)

F-statistics

P-value

Aβ42(pg/mL)a,b

 Mean (SD)

281 (77.8)

214 (90.5)

180 (60.7)

21.57

1.42e−08 ***

 Median [min, max]

266 [140, 449]

192 [105, 354]

169 [76.0, 405]

  

Total Tau (pg/mL)b

 Mean (SD)

52.2 (19.0)

70.0 (47.2)

105 (65.5)

15.59

1.18e−06 ***

 Median [min, max]

48.0 [16.8, 105]

59.5 [17.0, 195]

85.4 [30.0, 299]

  

Phosphorylated Tau (pg/mL)b

 Mean (SD)

22.1 (15.1)

29.9 (20.4)

42.9 (27.4)

9.702

1.36e−04 ***

 Median [min, max]

19.0 [0.0400, 67.7]

24.5 [7.00, 77.0]

37.0 [0.0800, 114]

  

Phosphorylated Tau/Aβ42 ratioa,b

 Mean (SD)

0.0970 (0.0852)

0.180 (0.161)

0.267 (0.170)

16

8.72e−07 ***

 Median [min, max]

0.0700 [0.00700, 0.422]

0.100 [0.0400, 0.530]

0.210 [0.0600, 0.599]

  

CEC—N9 microglial cells

 Mean (SD)

1.14 (0.319)

1.00 (0.246)

1.06 (0.272)

2.508

0.0863

 Median [min, max]

1.09 [0.660, 2.11]

0.960 [0.600, 1.50]

1.04 [0.600, 1.93]

  

CEC—SHY5Y neuroblastoma cellsa

 Mean (SD)

1.45 (0.571)

1.14 (0.474)

1.39 (0.473)

3.212

0.0442 *

 Median [min, max]

1.36 [0.570, 2.93]

1.04 [0.460, 2.25]

1.44 [0.740, 2.91]

  

Cholesterol (ng/mL)

 Mean (SD)

166 (42.4)

176 (68.0)

163 (32.9)

0.442

0.644

 Median [min, max]

160 [77.0, 270]

166 [89.0, 377]

164 [87.0, 230]

  

 Missing

4 (7.8%)

0 (0%)

3 (7.3%)

  

PL (nM)

 Mean (SD)

10900 (2130)

9540 (1720)

10400 (1700)

1.651

0.197

 Median [min, max]

11000 [6380, 16900]

10100 [7170, 13100]

10400 [6830, 15600]

  

ApoA1 (ng/mL)

 Mean (SD)

2280 (1560)

1700 (588)

2190 (1030)

2.208

0.115

 Median [min, max]

1840 [438, 6810]

1450 [1030, 3300]

2100 [601, 6330]

  

ApoE (ng/mL)b

 Mean (SD)

11000 (1680)

10900 (2130)

9810 (1890)

4.784

0.0103 *

 Median [min, max]

10900 [7390, 16100]

11000 [7310, 15000]

9340 [5910, 14000]

  

ApoJ (ng/mL)a

 Mean (SD)

9690 (4030)

7350 (2420)

9080 (3210)

3.158

0.0466 *

 Median [min, max]

8890 [2940, 19800]

7240 [3040, 10900]

8800 [2270, 17700]

  

 Missing

1 (2.0%)

0 (0%)

2 (4.9%)

  
  1. [1] All P-values are derived from one-way ANOVA
  2. [2] All continuous measures are reported as medians with min and max ranges, missing value counts, and corresponding percentage
  3. [3] CSF denotes cerebrospinal fluid, PL phosphorylated lipids, ApoA1 apolipoprotein A-I, ApoE apolipoprotein E, ApoJ Clusterin, Abeta42 42 amino acid form of beta amyloid
  4. [4] Cholesterol efflux capacity is expressed as a percentage of efflux in the sample, normalized to a reference sample
  5. [5] The Tukey HSD test was performed post hoc. We used a, b, and c to represent a significant difference in each comparison. a: MCI vs CN, b:AD vs CN, and c: AD vs MCI
  6. Significant P-values: *P < 0.05; **P < 0.01; ***P < 0.001
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Alzheimer's Research & Therapy

ISSN: 1758-9193