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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Fig. 1

Serum biomarker correlation matrix. Partial Spearman correlation matrix adjusted for covariates age, sex, BMI, and APOE status. Serum biomarker levels (yellow) were correlated against their CSF counterparts (CSF: serum), to CSF AD biomarkers (gray, Aβ42/40 ratio, p-tau-181, t-tau, neurogranin, and FABP-3), as well as to plasma levels of Nf-L determined in DELCODE (red). The upper panel depicts the strength of correlation (Spearman r), and the lower panel, significance (Spearman p). Between CSF and serum, several proteins showed weak to modest correlations, whereas others were not correlated at all. The strongest correlation was observed between serum and CSF CRP protein. FABP-3, ApoE, sAXL, and complement C4 showed weak correlations to amyloid. FABP-3 and YKL-40 were consistently correlated to CSF levels of tau isoforms and neurodegeneration markers. Plasma levels of Nf-L were correlated to several proteins from the serum panel, even if the respective proteins did not relate to their CSF counterparts or to CSF AD markers

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