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Table 3 Reasons to participate and not to participate in the four hypothetical protocols

From: Attitudes about involvement in hypothetical clinical trial protocols in Mexican and Mexican-American at risk for autosomal dominant Alzheimer’s disease

H1: Oral medication

Reasons to participate

Mexico (n=45)

U.S. (n=14)

  Benefits outweigh the risk

30 (67%)

10 (71%)

  Help future generations

39 (87%)

13 (93%)

  Other

0 (0%)

1 (7%)

Reasons to decline participation

(n= 4)

(n=9)

  Do not want to know my genetic status

1 (25%)

5 (56%)

  Risks and side effects are too high to justify possible benefits

1 (25%)

2 (22%)

  Other

2 (50%)

3 (33%)

H2: Vaccine trial

Reasons to participate

(n=34)

(n=12)

  Benefits outweight the risk

21 (62%)

8 (67%)

  Help future generations

25 (74%)

8 (67%)

  Other

1 (3%)

1 (8%)

Reasons to decline participation

(n=14)

(n=10)

  Do not want to know my genetic status

0 (0%)

5 (50%)

  Risks and side effects are too high to justify possible benefits

12 (86%)

4 (40%)

  Other

1 (7%)

0 (0%)

H3: Intravenous drug trial

Reasons to participate

(n=33)

(n=9)

  Benefits outweight the risk

22 (67%)

7 (78%)

  Help future generations

28 (85%)

7 (78%)

  Other

1 (3%)

0 (0%)

Reasons to decline participation

(n=16)

(n=12)

  Do not want to know my genetic status

4 (25%)

7 (58%)

  Risks and side effects are too high to justify possible benefits

9 (56%)

4 (33%)

  Other

3 (19%)

1 (8%)

H4: Neurosurgery

Reasons to participate

(n=16)

(n=3)

  Benefits outweight the risk

10 (62%)

2 (67%)

  Help future generations

15 (94%)

2 (67%)

  Other

0 (0%)

0 (0%)

Reasons to decline participation

(n=30)

(n=18)

  Do not want to know my genetic status

3 (10%)

7 (39%)

  Risks and side effects are too high to justify possible benefits

23 (77%)

11 (61%)

  Other

5 (17%)

3 (17%)

  1. H1, H2, H3, and H4, each refers to the four different hypothetical protocols respectively. U.S. United States