Fig. 3

Correlation between platforms in CSF and plasma. A Frequency distribution of correlation r values within subject between proteins commonly measured in the Olink and SomaScan platforms (left), MS depleted and Olink platforms (center), and MS depleted and SomaScan platforms (right), in CSF (top) and plasma (bottom). The vertical red lines indicate the median correlations. The number of proteins used for each correlation analysis is provided in the respective panel. All correlation values are provided in Additional file 2: Supplementary Tables 12-17, with individual correlation plots provided in Additional file 1: Extended Data. B Distribution of correlation r values for each cross-platform measurement in CSF and plasma considering only proteins that are significantly differentially expressed in a given platform. For each comparison, differentially expressed proteins are restricted to the first platform listed (e.g., MS.Olink indicates proteins differentially expressed by MS that have a corresponding measurement in Olink). The median correlation for each comparison is provided above the respective boxplot. The red dashed lines for each cross-platform measurement correspond to the median correlation considering all proteins as shown in A, with the correlation value provided below in red. Boxplots represent the median, 25th, and 75th percentiles, and box hinges represent the interquartile range of the two middle quartiles within a group. Datapoints up to 1.5 times the interquartile range from box hinge define the extent of whiskers (error bars)