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Table 1 Demographic and biomarker information from the CSF samples obtained from the Gothenburg (Sweden) and Barcelona (Spain) cohorts

From: Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer’s disease patients

Cohort: Gothenburg (Sweden)

 

Control

Alzheimer’s disease

APOE

ε3/ε3

ε3/ε4

All

ε3/ε3

ε3/ε4

ε4/ε4

All

N

9

5

14

15

15

15

45

Age (years)

69±2

62±5

67±3

79±2

78±1

73±1

77±1*

Age (range)

60–81

44–75

44–81

62–88

69–84

63–83

62–88

Female/male

5/4

2/3

7/7

11/4

11/4

9/6

31/14

CSF Aβ42 (pg/mL)

845±96

746±121

804±74

470±13*

480±8*

419±21

457±10*

CSF tau (pg/mL)

317±53

303±34

312±35

816±88*

917±112*

731±53

840±52*

Cohort: Barcelona (Spain)

 

Control

Alzheimer’s disease

APOE

ε3/ε3

ε3/ε4

All

ε3/ε3

ε3/ε4

ε4/ε4

All

N

5

5

10

10

10

9

29

Age (years)

71±2

67±52

69±2

75±2

73±2

72±2

73±1*

Age (range)

66–76

60–72

60–76

64–84

64–83

61–85

61–85

Female/male

1/4

2/3

3/7

7/3

2/8

7/2

16/13

CSF Aβ42 (pg/mL)

1139±248

1010±116

1075±131

607±60*

543±37*

493±62

549±31*

CSF tau (pg/mL)

295±49

261±23

278±26

778±94*

624±62*

908±81

765±50*

  1. Values are represented as mean ± SEM. *Significantly different (T-test, p< 0.05) from the control group with the same APOE genotype or regardless of the genotype (“All” columns)