Outcome | Leptin × time interaction |
---|
Aβ (+) | Aβ (−) |
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Beta | SE | p-value | Beta | SE | p-value |
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ADAS-Cog | 0.091 | 0.059 | 0.128 | 0.000 | 0.030 | 0.988 |
PHC, right | 0.001 | 0.001 | 0.485 | 0.001 | 0.001 | 0.190 |
PHC, left | 0.001 | 0.001 | 0.428 | 0.000 | 0.001 | 0.774 |
ERC, right | − 0.001 | 0.002 | 0.723 | 0.000 | 0.002 | 0.998 |
ERC, left | 0.000 | 0.002 | 0.833 | 0.000 | 0.002 | 0.890 |
- Models were adjusted for the following covariates: baseline age, sex, years of education, number of APOE ε4 genotype, BMI, history of hypertension, diabetes mellitus, smoking and alcohol abuse, the levels of plasma insulin, and eGFR. The levels of plasma leptin and insulin levels were log-transformed
- Abbreviations: Aβ amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Sscale-Cognitive subscale, APOE apolipoprotein E, BMI body mass index, ERC entorhinal cortex, eGFR estimated glomerular filtration rate, PHC parahippocampal cortex, SE standard error