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Table 5 Predictive effect of the interaction between baseline leptin and time since baseline

From: Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology

Outcome

Leptin × time interaction

Aβ (+)

Aβ (−)

Beta

SE

p-value

Beta

SE

p-value

ADAS-Cog

0.091

0.059

0.128

0.000

0.030

0.988

PHC, right

0.001

0.001

0.485

0.001

0.001

0.190

PHC, left

0.001

0.001

0.428

0.000

0.001

0.774

ERC, right

− 0.001

0.002

0.723

0.000

0.002

0.998

ERC, left

0.000

0.002

0.833

0.000

0.002

0.890

  1. Models were adjusted for the following covariates: baseline age, sex, years of education, number of APOE ε4 genotype, BMI, history of hypertension, diabetes mellitus, smoking and alcohol abuse, the levels of plasma insulin, and eGFR. The levels of plasma leptin and insulin levels were log-transformed
  2. Abbreviations: amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Sscale-Cognitive subscale, APOE apolipoprotein E, BMI body mass index, ERC entorhinal cortex, eGFR estimated glomerular filtration rate, PHC parahippocampal cortex, SE standard error