Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology

Table 4 Predictive effect of the interaction between baseline adiponectin and time since baseline

Outcome	Adiponectin × time interaction
	Aβ (+)			Aβ (−)
	Beta	SE	p-value	Beta	SE	p-value
ADAS-Cog	0.224	0.093	0.018	− 0.018	0.054	0.744
PHC, right	− 0.004	0.002	0.012	− 0.002	0.002	0.529
PHC, left	− 0.004	0.002	0.025	− 0.002	0.003	0.411
ERC, right	− 0.007	0.003	0.024	0.010	0.005	0.042
ERC, left	− 0.005	0.003	0.122	0.002	0.004	0.690
BMI change	− 0.004	0.016	0.805	0.054	0.042	0.216

Models were adjusted for the following covariates: baseline age, sex, years of education, number of APOE ε4 genotype, BMI, history of hypertension, diabetes mellitus, smoking and alcohol abuse, the levels of plasma insulin, and eGFR. The levels of plasma adiponectin and insulin levels were log-transformed
Abbreviations: Aβ amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognitive subscale, APOE apolipoprotein E, BMI body mass index, ERC entorhinal cortex, eGFR estimated glomerular filtration rate, PHC parahippocampal cortex, SE standard error

ISSN: 1758-9193