Alzheimer's Research & Therapy

Table 3 Results of the cross-sectional multiple regression model predicting adipokine levels at baseline

From: Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology

Predictor	Outcome—adiponectin			Outcome—leptin
Predictor	Beta	SE	p-value	Beta	SE	p-value
Intercept	1.480	0.491	0.003	− 0.952	0.587	0.107
Aβ (+)	− 0.028	0.050	0.580	0.059	0.060	0.333
ADAS-Cog	0.007	0.005	0.158	0.006	0.006	0.310
PHC, right	0.115	0.081	0.160	− 0.014	0.097	0.884
PHC, left	− 0.263	0.076	< 0.001	− 0.007	0.090	0.934
ERC, right	0.003	0.051	0.958	− 0.062	0.061	0.311
ERC, left	0.069	0.051	0.176	0.016	0.061	0.796
Age	0.000	0.003	0.935	− 0.001	0.003	0.806
Sex (female)	0.125	0.043	0.004	0.481	0.051	< 0.001
Education	− 0.003	0.007	0.707	0.000	0.008	0.966
APOE ε4	0.009	0.029	0.762	− 0.038	0.035	0.286
BMI	− 0.025	0.008	0.001	0.074	0.009	< 0.001
Hypertension	− 0.004	0.037	0.920	0.088	0.045	0.050
Diabetes mellitus	− 0.037	0.057	0.518	− 0.110	0.069	0.110
PPARγ agonist	0.306	0.232	0.190	− 0.127	0.278	0.647
Smoking	0.050	0.040	0.219	0.046	0.048	0.337
Alcohol	− 0.015	0.083	0.858	− 0.047	0.100	0.637
Insulin	− 0.132	0.060	0.030	0.332	0.072	< 0.001
eGFR	0.000	0.001	0.832	− 0.002	0.002	0.123

The levels of plasma adiponectin, leptin, and insulin were log-transformed
Abbreviations: Aβ amyloid-β, ADAS-Cog Alzheimer’s Disease Assessment Scale-Cognitive subscale, APOE apolipoprotein E, BMI body mass index, ERC entorhinal cortex, eGFR, estimated glomerular filtration rate, PHC parahippocampal cortex, PPARγ peroxisome proliferator-activated receptor γ, SE standard error

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com