Fig. 2
Bootstrapped linear models (1000 iterations) revealed that partial R2 values (explained variance in annual cognitive changes) were higher for cognitive-domain-specific tau than for global or temporal tau-PET. The boxplots illustrate the partial R2 distributions for episodic memory, language, executive functioning, and visuospatial abilities within the AD-spectrum (ADNI cohort: A–D; A05 cohort: E–H). The models were controlled for age, sex [in ADNI: education], clinical status, baseline score of the respective cognitive test, and APOE4 status. R2-distributions across different regions of interests (global vs. temporal vs. cognitive-domain-specific tau-PET) were compared with paired t-tests. 95% confidence intervals for the mean are displayed as horizontal lines. Within each panel, the tau-PET ROI with the highest explained variance is highlighted by an underscore. *p < 0.05, **p < 0.01, ***p < 0.001