Table 1 Statistically significant results reflecting the effect of genetically predicted longer telomere length on neuroimaging outcomes
High genetic predisposition to AD (N= 295) | ||||||||
AD signature | Aging signature | |||||||
Causal inference methods | β | SE | p-value | q-value* | β | SE | p-value | q-value* |
Inverse-variance weighted | 0.064 | 0.029 | 2.89E−02 | 3.18E−02 | 0.062 | 0.029 | 3.18E−02 | 3.18E−02 |
Maximum likelihood | 0.064 | 0.029 | 2.88E−02 | 3.15E−02 | 0.062 | 0.029 | 3.15E−02 | 3.15E−02 |
Weighted median | 0.064 | 0.039 | 9.91E−02 | 1.98E−01 | 0.042 | 0.038 | 2.65E−01 | 2.65E−01 |
Weighted mode | 0.058 | 0.048 | 2.31E−01 | 3.68E−01 | 0.042 | 0.047 | 3.68E−01 | 3.68E−01 |
Sensitivity methods | p-value | p-value | ||||||
Cochran Q, heterogeneity test | 0.995 | 0.998 | ||||||
MR-PRESSO, global test | 0.997 | 0.998 | ||||||
MR-Egger, intercept test | 0.998 | 0.939 | ||||||