Fig. 1
From: Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
Gossypetin ameliorates spatial learning and memory of 5xFAD mice. A Timeline of gossypetin administration for 5xFAD mice (n = 17 ~ 21 per group). B, C 5xFAD mice were tested with Y-maze alteration test measuring percentage of alteration (B) and number of total arm entry (C). D–G 5xFAD mice were trained for 5 days for Morris Water Maze test, and escape latency was recorded each day of training. Probe test was conducted on the 6th day (D). In probe test, percentage of target (platform) quadrant occupancy (E), number of target crossing (F), and total traveled distance were recorded (G). H Bar graph represents AChE activity inhibition percentage of gossypetin (100μM) with donepezil (1μM) as positive control. The error bars represent the mean ± SD (B-G) or mean ± SEM (H), **** p < 0.0001, **p < 0.01, *p < 0.05, ns = not significant, two-way ANOVA followed by Tukey’s multiple comparisons test (B, C, E, F, G), and Student’s t-test (H)