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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice

Fig. 5

LPD treatment enhanced PINK1/Parkin-mediated mitophagy in vitro in a PPARγ-dependent manner. A Cotreatment with GW9662 or Mdivi-1 abolished the effects of LPD on the protein expression of PPARγ, PINK1, p-Parkin (Ser65), LC3-II, LC3-I, and SQSTM1/p62. B Quantitative analysis of mitophagy and protein expression. C LPD treatment significantly increased OCR, ATP production, maximal respiration, spare respiratory capacity, and basal respiration in APP/PS1 cells. Data are expressed as the means ± SD (n = 6 per group) and were analyzed by one-way ANOVA followed by Tukey’s post hoc test. ##, P < 0.01 versus control; **, P < 0.01 versus LPD treatment

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Alzheimer's Research & Therapy

ISSN: 1758-9193