Fig. 4From: Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 miceLPD treatment enhanced PINK1/Parkin-mediated mitophagy in vivo in a PPARγ-dependent manner. A LPD treatment markedly increased mitophagy in the hippocampi of APP/PS1 mice (n = 3 per group). Arrows indicate mitophagy. B Quantitative analysis of mitophagy and protein expression. C Representative western blot images of PPARγ, PINK1, p-Parkin (Ser65), LC3-II, LC3-I, and SQSTM1/p62 in the hippocampi of mice (n = 6 per group). Data are expressed as the means ± SD and were analyzed by two-way ANOVA followed by Tukey’s post hoc test. ##, P < 0.01 versus WT; **, P < 0.01 versus APP/PS1 mice. &&, P < 0.01 versus LPD-treated APP/PS1 miceBack to article page