Fig. 3
LPD treatment reduced Aβ plaques and increased brain glucose uptake in a PPARγ-dependent manner. The brain sections (n = 3 per group) were stained by immunofluorescence using an anti-Aβ antibody. A Immunofluorescence images of Aβ plaques in the hippocampus. Scale bar = 200 μm. Arrows indicate Aβ plaques. B The percentage of Aβ plaque area in the hippocampus was quantified. The insoluble and soluble forms of Aβ40 and Aβ42 in the hippocampus (n = 8 per group) were detected by ELISA. C MicroPET imaging with 18F-FDG was used to investigate the effect of LPD on brain glucose uptake in APP/PS1 mice (n = 10 per group). D LPD treatment markedly increased the standardized uptake value in APP/PS1 mice. Data are expressed as the means ± SD and were analyzed by two-way ANOVA followed by Tukey’s post hoc test. ##, P < 0.01 versus WT; **, P < 0.01 versus APP/PS1 mice. &&, P < 0.01 versus LPD-treated APP/PS1 mice