Fig. 2

Serum total TDP-43 concentrations in individual subgroups based on the clinical phenotypes of frontotemporal dementia (FTD), in the total FTD group including all of the phenotypes, and in healthy controls (HC). The values were obtained using natural logarithmic transformation. Black horizontal lines indicate group median and interquartile ranges. p-values are calculated with a general linear model with age and gender as covariates. Only significant p-values are indicated. Abbreviations: TDP-43, TAR DNA-binding protein 43; FTD-MND, frontotemporal dementia with motor neuron diseases; bvFTD, behavioral variant frontotemporal dementia; nfvPPA, non-fluent variant primary progressive aphasia; svPPA, semantic variant primary progressive aphasia; PSP, progressive supranuclear palsy