Fig. 4
Long QPPs to investigate the propagation of network activity. A T-maps (two-tailed one-sample t-tests, FDR p < 0.05, minimal cluster size 10) show the long rQPP in each group. Colors indicate T-values. B Average BOLD time courses within regions of interest during 9-s QPPs. C Peak timings averaged across occurrences for each voxel within a certain region. Dots represent the distribution of average peak timing of individual region of interest (ROI)-specific voxels; the black lines represent the mean peak timing across all ROI-specific voxels. D Differences (peaky − peakx) in mean peak timing across voxels for each connection. The top half represents the wild-type (WT) animals, while the lower half represents the TgF344-AD rats (Tg). Unpaired two-sample t-tests (FDR p < 0.05) between regions were performed to evaluate if peak timing was significantly different between ROIs. CG cingulate cortex, OFC orbitofrontal cortex, RSC retrosplenial cortex, HC hippocampus, BFB basal forebrain. *p < 0.05