Fig. 3

Spatiotemporal alterations in network activity in 4-month-old TgF344-AD rats (Tg) as compared to control littermates (WT). A T-maps (two-tailed one-sample t-tests, FDR p < 0.05, minimal cluster size 10) show the two rQPPs in each group. B T-maps of the two-sample t-test (two-tailed two-sample t-tests, FDR p < 0.05, minimal cluster size 10) between the rQPPs of TgF344-AD and WT rats. The warm colors (red/yellow) indicate a significant difference in BOLD activity between groups for voxels which are positive (activated) in the original QPP of the WT group. The right color bar (light blue/dark blue) indicates significant genotype differences for voxels which were deactivated in the original QPP of the WT group. For the QPP-DMLN, TgF344-AD rats demonstrate a significantly lower involvement of the OFC, PrL, Ent, and BFB is observed (arrowheads), together with a significantly increased activity of the Cg (arrow). For the QPP-LCN.⁺, only motor cortices and somatosensory cortex show significantly stronger activation in the TgF344-AD rats. C Comparison of cluster-wise occurrence rates between groups (mean ± SEM, two-sample t-test, two-tailed, FDR, p < 0.05) demonstrates significantly lower occurrences in the TgF344-AD rats for both QPPs. *p < 0.05