Table 2 Uni- and multivariable correlates of Ln (neurofilament light chain)
Number | Separate models, univariable (enter) | Separate models, multivariable (enter) | Separate models, multivariable (backward) | Combined model, multivariable (enter) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T | p-value | R2 | VIF | T | p-value | VIF | T | p | VIF | T | p-value | ||
Clinical parameters | R2 = 0.53 | R2 = 0.47 | R2 = 0.48 | ||||||||||
Age (years) | 146 | 8.19 | < 0.001 | 0.32 | 1.86 | 3.73 | < 0.001 | 1.22 | 5.86 | < 0.001 | 1.83 | 4.57 | < 0.001 |
Estimated GFR (ml/min/1.73 m2) | 146 | − 7.58 | < 0.001 | 0.29 | 2.18 | − 2.78 | 0.006 | 1.45 | − 3.44 | 0.001 | 1.55 | − 3.10 | 0.002 |
Urea (mg/dl) | 146 | 6.09 | < 0.001 | 0.20 | 2.09 | 0.80 | 0.425 | ||||||
NT-proBNP (pg/ml) | 140 | 5.09 | < 0.001 | 0.16 | 1.62 | 2.20 | 0.030 | 1.20 | 2.75 | 0.007 | 1.35 | 2.58 | 0.011 |
Mean corpuscular hemoglobin concentration (g/dl) | 146 | − 4.34 | < 0.001 | 0.12 | 2.02 | − 0.58 | 0.560 | ||||||
Left-atrial volume index (ml/m2) | 143 | 3.62 | < 0.001 | 0.09 | 1.52 | 0.94 | 0.348 | ||||||
Thrombocytes (103/μl) | 145 | − 3.02 | 0.003 | 0.06 | 1.39 | − 1.41 | 0.160 | ||||||
Systolic blood pressure (mmHg) | 145 | 3.25 | 0.001 | 0.07 | 1.37 | 1.58 | 0.116 | ||||||
Diuretics (n/y) | 146 | − 4.73 | < 0.001 | 0.13 | 1.37 | − 1.93 | 0.055 | 1.18 | − 2.07 | 0.051 | 1.21 | − 1.97 | 0.057 |
6-min walking test distance (m) | 138 | − 3.34 | 0.001 | 0.08 | 1.55 | 1.90 | 0.060 | ||||||
Hemoglobin (g/dl) | 146 | − 3.67 | < 0.001 | 0.09 | 1.94 | 0.07 | 0.948 | ||||||
Duration of heart failure (years) | 145 | 2.60 | 0.010 | 0.05 | 1.23 | 0.74 | 0.461 | ||||||
Alanine aminotransferase (U/l) | 145 | − 3.35 | 0.001 | 0.07 | 1.32 | − 0.90 | 0.368 | ||||||
Hemoglobin A1c (%) | 145 | 2.11 | 0.037 | 0.03 | 1.22 | 1.28 | 0.202 | ||||||
Uric acid (mg/dl) | 146 | 2.08 | 0.039 | 0.03 | 1.36 | − 1.79 | 0.076 | ||||||
MRI parameters | R2 = 0.41 | R2 = 0.41 | |||||||||||
White matter hyperintensity volume (mm3) | 146 | 3.70 | < 0.001 | 0.30 | 1.06 | 2.84 | 0.005 | 1.06 | 2.90 | 0.004 | 1.15 | 1.11 | 0.267 |
Cerebral atrophy score (1–8) | 146 | 4.37 | < 0.001 | 0.34 | 1.17 | 3.33 | 0.001 | 1.06 | 3.69 | < 0.001 | 1.63 | 0.23 | 0.816 |
Hippocampal atrophy score (0–4) | 146 | 2.08 | 0.039 | 0.17 | 1.13 | 0.57 | 0.573 | ||||||
Cognitive domains | R2 = 0.06 | R2 = 0.06 | |||||||||||
Intensity of attention (T-score) | 146 | − 0.83 | 0.407 | 0.01 | |||||||||
Visual/verbal memory (T-score) | 146 | − 3.12 | 0.002 | 0.06 | 1.00 | − 3.12 | 0.002 | 1.00 | − 3.12 | 0.002 | 1.13 | − 0.63 | 0.529 |
Executive functions (T-score) | 146 | − 1.11 | 0.267 | 0.01 | |||||||||
Selectivity of attention (T-score) | 146 | − 1.34 | 0.181 | 0.01 | |||||||||
Working memory (T-score) | 146 | − 0.89 | 0.374 | 0.01 | |||||||||
Visual/verbal fluency (T-score) | 146 | − 0.25 | 0.805 | 0.00 | |||||||||