Fig. 7
Microgliosis in brain of 12 months old mice. A Photomicrographs of activated IBA-1, a marker of microgliosis in brain. B Activated IBA-1 immunostained area in brain atlas section +1.94 mm and atlas section −3.08 mm. C Activated IBA-1 number in brain atlas sections +1.94 mm and atlas section -3.08 mm. Scale bars represent 1 mm for atlas section +1.94 mm and 2.5 mm for atlas section −3.08 mm. Data is presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p<0.001; a, as compared to the control group; b, as compared to the APP-NE group. Control group, C57BL/6 (n = 5). APP-NE group, APPNL-G-F with no exercise (n = 4). APP-Ex group, APPNL-G-F mice exposed to exercise (n = 4)