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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APPNL-G-F mouse model of Alzheimer disease following long-term voluntary exercise

Fig. 5

Amyloid plaque distribution in brain of 12-month-old APPNL-G-F mice. A Photomicrographs of amyloid plaques stained with methoxy-XO4 (green) in the brain. B, C Corresponding distributions of plaque size by total number of plaques. D Percent amyloid plaque area in brain. E Total amyloid plaques number in the brain. Scale bars represent 1 mm for atlas section +1.94 mm and 2.5 mm for atlas section −3.08 mm. Data is presented as mean ± SEM. *p < 0.05—as compared to the APP-NE group. APP-NE group, APPNL-G-F with no exercise (n = 4). APP-Ex group, APPNL-G-F mice exposed to exercise (n = 4)

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Alzheimer's Research & Therapy

ISSN: 1758-9193