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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APPNL-G-F mouse model of Alzheimer disease following long-term voluntary exercise

Fig. 3

Effects of long-term voluntary exercise on spatial learning and memory functions of 12-month-old APPNL-G-F mice in the MWT. A Mean latency to find the hidden escape platform during the acquisition phase. B Mean swim speed during the acquisition phase. C Percent thigmotaxis shown by mice on each day during the acquisition phase. D Percent thigmotaxis shown by mice during the acquisition phase (average of days 1–8). E Percent time spent by mice in target quadrant and average of other quadrants during the probe trial. F Average proximity to platform during probe trial. Data is presented as mean±SEM. *p < 0.05, **p < 0.01, ***p < 0.001 are considered as statistically significant. a, as compared to control group; b, as compared to APP-NE group. Control group, C57BL/6 (n= 10). APP-NE group, APPNL-G-F with no exercise (n = 10). APP-Ex group- APPNL-G-F mice exposed to exercise (n = 15)

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