Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia

Table 1 Demographic characteristics of human brain samples

Brain region and source	Dorsolateral prefrontal cortex (ROSMAP, RADC)
Clinical diagnosis	NCI	NCI	AD dementia	AD dementia
Genotype	E3/E3	E3/E4	E3/E3	E3/E4
Sample size, n	12	9	12	9
Age at death, years ± SD^a	85 ± 6	87 ± 5	92 ± 6	94 ± 5
Sex, female (%)^b	6 (50)	5 (56)	5 (42)	6 (67)
Education, years ± SD^c	21 ± 3	19 ± 2	17 ± 3	17 ± 3
Global cognitive function ± SD^d	0.3 ± 0.3	0.4 ± 0.4	−1.7 ± 1.0	−2.8 ± 0.8
Neuritic plaque burden ± SD^e	0.5 ± 0.7	0.3 ± 0.5	0.9 ± 0.6	1.9 ± 0.6
Overall amyloid level ± SD^f	2.8 ± 3.6	3.2 ± 4.6	5.2 ± 4.7	7.7 ± 4.9
Braak stage, mean ± SD^g	3.3 ± 0.8	3.1 ± 0.9	3.9 ± 1.4	5 ± 0
I	0	0	1	0
II	2	3	2	0
III	5	2	0	0
IV	4	4	3	0
V	1	0	6	9

Abbreviations: NCI no cognitive impairment, AD Alzheimer’s disease, RADC Rush Alzheimer’s Disease Center
^aAge was different between APOE3/3 NCI and APOE3/3 AD groups, APOE3/3 NCI and APOE3/4 AD groups, and between APOE3/4 NCI and APOE3/4 AD groups; one-way ANOVA tests
^bProportion of males and females did not differ between groups; chi-squared test
^cEducation was different between APOE3/3 NCI and APOE3/3 AD groups; one-way ANOVA tests
^dAverage of Z-scores from 19 cognitive tests; scores provided by RADC
^eMeasure of neuritic plaque burden averaged across 5 cortex and hippocampus brain regions; scores provided by RADC
^fPercent area of cortex occupied by amyloid beta; scores provided by RADC
^gBraak stage was different between APOE3/3 NCI and APOE3/4 AD groups and between APOE3/4 NCI and APOE3/4 AD groups; one-way ANOVA tests

ISSN: 1758-9193