Fig. 3
AD dementia brains from APOE4 carriers display higher levels of pro-inflammatory and pro-resolving mediator lipids indicating chronic unresolved inflammation. * p < 0.05, ** p < 0.01, *** p < 0.001; p-values for β-estimates were derived from the regression model adjusted for age and education. Abbreviations: AA, arachidonic acid; 5-HETE, 5-hydroxyeicosatetraenoic acid; PGs, prostaglandins; TXB2, thromboxane B2; 12-HHT, 12-hydroxyheptadecatrienoic acid; LXs, lipoxins; LTB4, leukotriene B4; EPA, eicosapentaenoic acid; 5-HEPE, 5-hydroxyeicosapentaenoic acid; RvE3, resolvin E3; DHA, docosahexaenoic acid; 17-HDHA, 17-hydroxydocosahexaenoic acid; RvDs, D-series resolvins; NPD-1, neuroprotectin D1; DPA, docosapentaenoic acid