Skip to main content

Table 3 Associations of neurocognitive domains and imaging variables with AD subtypes (MA subtype as the reference).

From: Imaging markers of cerebral amyloid angiopathy and hypertensive arteriopathy differentiate Alzheimer disease subtypes synergistically

Domain/Variable

Typical

LP

HS

OR

95%CI

P value

OR

95%CI

P value

OR

95%CI

P value

MMSE

0.96

(0.85–1.09)

0.514

0.82

(0.69–0.96)

0.015*

1.02

(0.90–1.15)

0.750

MoCA

0.92

(0.80–1.06)

0.259

0.76

(0.61–0.94)

0.014*

1.04

(0.92–1.19)

0.486

CDR-SB

1.27

(0.84–1.91)

0.254

1.59

(0.93–2.71)

0.086

0.77

(0.46–1.27)

0.317

Orientation

0.75

(0.33–1.69)

0.492

0.18

(0.05–0.70)

0.013*

1.17

(0.60–2.30)

0.640

Attention

0.69

(0.34–1.41)

0.307

0.15

(0.04–0.52)

0.003**

1.07

(0.55–2.07)

0.838

STM (registration)

0.61

(0.27–1.36)

0.225

0.26

(0.10–0.70)

0.007**

1.07

(0.57–2.01)

0.823

STM (recall)

0.977

(0.51–1.86)

0.944

0.47

(0.17–1.28)

0.141

1.12

(0.61–2.04)

0.704

Language

0.62

(0.29–1.30)

0.207

0.21

(0.07–0.66)

0.008**

0.97

(0.48–1.99)

0.948

Visual execution

0.68

(0.33–1.39)

0.288

0.12

(0.03–0.54)

0.006**

0.77

(0.40–1.51)

0.456

CMB

0.98

(0.87–1.10)

0.806

0.88

(0.69–1.12)

0.297

0.96

(0.83–1.11)

0.590

Lacune

1.01

(0.75–1.34

0.961

1.04

(0.75–1.44)

0.819

1.24

(0.93–1.68)

0.147

Periventricular WMH

2.62

(1.23–5.57)

0.012*

2.06

(0.85–4.97)

0.108

1.22

(0.63–2.33)

0.549

Deep WMH

1.65

(0.93–2.96

0.089

1.18

(0.61–2.30)

0.630

1.17

(0.68–2.00)

0.555

WMH burden

1.11

(0.94–1.32)

0.244

1.14

(0.93–1.40)

0.200

0.994

(0.82–1.20)

0.947

BG PVSE

1.03

(0.57–1.87)

0.914

0.99

(0.49–1.99)

0.988

0.74

(0.39–1.37)

0.340

CSO PVSE

1.45

(0.84–2.50)

0.182

1.24

(0.65–2.40)

0.516

1.13

(0.67–1.89)

0.635

PVSE burden

1.25

(0.86–1.80)

0.237

1.02

(0.70–1.47)

0.924

1.03

(0.72–1.47)

0.850

Global SVD score

1.67

(1.11–2.52)

0.009**

1.16

(0.75–1.79)

0.502

1.23

(0.85–1.78)

0.269

CAA-SVD score

1.53

(0.79–2.95)

0.204

1.14

(0.56–2.33)

0.767

1.09

(0.63–1.90)

0.761

HA-SVD score

1.93

(1.10–3.52)

0.034*

2.57

(1.23–5.37)

0.012*

3.30

(1.58–6.85)

0.001**

  1. ORs determined by multivariate logistic regression, adjusted for age, sex, vascular risk factors, and CDR
  2. LP limbic-predominant type, HS hippocampal-sparing type, MA minimal-atrophy type, MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, CDR clinical dementia rating score, CDR-SB clinical dementia rating-sum of boxes, STM short-term memory, CMB cerebral microbleeds, WMH white matter hyperintensity, BG basal ganglia, CSO centrum semiovale, PVSE perivascular space enlargement, SVD small vessel disease, CAA cerebral amyloid angiopathy, HA hypertensive arteriopathy
  3. *p < 0.05
  4. **p < 0.01