Alzheimer's Research & Therapy

Table 3 Results from MANOVA/MANCOVA and Regression analyses investigating the individual and complementary value of the VSTMBT and FCSRT (HOA healthy older adults, aMCI amnestic MCI, maMCI multi-domain amnestic MCI, naMCI non-amnestic MCI; see text for description)

From: Memory markers in the continuum of the Alzheimer’s clinical syndrome

	HOA vs eMCI				HOA vs non-converter (!)				HOA vs converter ($!)
	MANOVA		Regression (14%,p=0.001)		MANCOVA		Regression (57%,p<0.001)		MANCOVA		Regression (65%,p<0.001)
	F	p	t	p	F	P	t	P	F	p	t	p
VSTMB (% recognition)	12.19	0.001	− 3.49	0.001	20.26	<0.001	− 5.32	<0.001	22.20	<0.001	− 2.98	<0.001
FCSRT (free recall)	4.39	0.040	− 1.86	0.067	41.54	<0.001	− 3.11	0.003	94.20	<0.001	− 8.39	0.004
	eMCI vs non-converter (!)				eMCI vs converter				Non-converter vs converter
	MANCOVA		Regression (30.8%,p<0.001)		MANOVA		Regression (44.4%,p<0.001)		MANOVA		Regression (6.1%,p=0.025)
	F	p	t	p	F	P	t	P	F	p	t	p
VSTMB (% recognition)	2.27	0.137	− 0.93	0.354	7.13	0.010	− 0.84	0.403	1.20	0.277	− 0.45	0.651
FCSRT (free recall)	16.20	<0.001	− 4.02	<0.001	49.78	<0.001	− 7.06	<0.001	5.24	0.025	− 2.29	0.025

$: adjusting for age; !: adjusting for education; % = percentage of variance accounted for by the model which comprises both predictors. Bold font: excluded from model. MANCOVA were conducted when either age or education was significant; otherwise, MANOVA models were used; t-values correspond to separate hypothesis tests for each predictor variable (with the corresponding p-value) (see Supplementary Table 1 for full report on regression models)

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