Table 2 Bivariate analyses. Associations between the residual measure and demographic, co-morbidity, and biomarker variables. Pearson correlation coefficients with bootstrapped 95% CIs for continuous variables and independent samples t values for binary variables with p values before and after FDR correction are presented

Age at baseline

−0.11 (−0.21 to −0.02)

-

0.029

0.064

Sex

-

−3.00

0.003

0.009

Years of education

0.04 (−0.06 to 0.14)

-

0.431

0.571

ICV

−0.17 (−0.27 to −0.07)

-

< 0.001

0.005

WML volume

−0.16 (−0.25 to −0.07)

-

0.002

0.008

APOEe4 allele

-

−2.71

0.007

0.018

Low CSF Aβ42/40 ratio

-

−4.05

< 0.001

< 0.001

CSF P-tau181

−0.22 (−0.32 to −0.12)

-

< 0.001

< 0.001

CSF NfL

−0.34 (−0.44 to −0.23)

-

< 0.001

< 0.001

CSF sTREM2

−0.07 (−0.16 to 0.02)

-

0.183

0.305

CSF neurogranin

−0.10 (−0.19 to 0.00)

-

0.059

0.118

CSF GFAP

−0.15 (-0.26 to −0.05)

-

0.003

0.009

Smoking (current or former)

-

−0.05

0.958

0.958

Hypertension

-

1.08

0.281

0.432

Hyperlipidaemia

-

0.88

0.382

0.546

Diabetes mellitus

-

−0.35

0.726

0.807

Ischemic heart disease

-

−0.12

0.903

0.951

Atrial fibrillation

-

−0.74

0.457

0.571

Congestive heart failure

-

0.56

0.575

0.676

Stroke/TIA

-

−1.40

0.178

0.305