Table 1 Baseline F-PACK characteristics stratified for APOE4 polymorphism status for individuals with baseline and follow-up amyloid-PET. Data are reported as median and range (minimum to maximum) for continuous variables and numerical for categorical variables. Wilcoxon rank sum test with continuity correction or Welch two-sample t-tests were used for continuous data, depending on data normality. χ2 tests have been used for categorical data. ε2ε3 N = 7; ε2ε4 N = 2; ε3ε3 N = 42; ε3ε4 N = 37; ε4ε4 N = 2. Total N = 90
APOE4 non-carrier (n=49) | APOE4 carrier (n=41) | Statistics | |
|---|---|---|---|
Sex (male/female) | 24/25 | 22/19 | Χ2 = 0.05, p = 0.82 |
BDNF 66 met carriers | 24 | 23 | Χ2 = 0.21, p = 0.64 |
Age (years) | 67 (52–80) | 68 (56–79) | T = –0.18, p = 0.86 |
Education (years) | 14 (8–20) | 16 (9–23.5) | T = 1.76, p = 0.08 |
MMSE | 29 (27–30) | 29 (27–30) | W = 1022.5, p = 0.88 |
CDR | 0 | 0 | NA |
AVLT TL (/75) | 47 (30–69) | 46 (35–68) | T = − 0.16, p = 0.87 |
AVLT %DR | 85.7 (30–107.7) | 86.7 (58.3–107.7) | W = 1039.5, p = 0.78 |
BSRT TR (/12) | 8.2 (5.6–10.8) | 7.9 (4.9–10.5) | T = − 0.94, p = 0.35 |
BSRT DR (/12) | 8 (2–12) | 8 (3–12) | W = 932.5, p = 0.56 |
BNT (/60) | 57 (46–60) | 57 (41–60) | W = 1028.5, p = 0.85 |
AVF (# words) | 23 (14–40) | 23 (14–42) | T = 0.50, p = 0.62 |
LVF (# words) | 36 (14–65) | 37 (9–61) | T = − 0.05, p = 0.96 |
PALPA49 (/30) | 28 (20–30) | 27 (23–30) | W = 981.5, p = 0.85 |
RPM (/60) | 46 (22–57) | 45 (22–57) | W = 864, p = 0.26 |
TMT B/A | 2.2 (1.2–4.8) | 2.4 (1.0–4.8) | T = 0.69, p = 0.49 |
Baseline Centiloid | 4.8 (− 14.1–99.8) | 7.7 (− 14.8–116.8) | W = 1163, p = 0.20 |
Baseline amyloid positivity | 4 (8%) | 5 (12%) | Χ2 = 0.08, p = 0.78 |
Follow-up amyloid positivity | 7 (14%) | 14 (34%) | Χ2 = 3.87, p = 0.049 |
Amyloid rate of change | − 0.03 (− 3.03–4.22) | 1.06 (− 2.85–13.92) | W = 1313, p = 0.01 |
Time interval (years) | 6.1 (4.0–10.9) | 5.4 (3.4–10.0) | W = 675, p = 0.008 |