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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults

Fig. 3

Regression plots for PRSnoAPOE+APOEε2+ε4 at pT = 5 × 10−8 and amyloid rate of change. A For the whole cohort. N = 90. B When the outlier for amyloid rate of change is removed. N = 89. The shape indicates amyloid status based on CL ≥ 23.5 [27]: amyloid negative at both time points (triangle, N = 69); amyloid negative at baseline and amyloid positive at follow-up (circle, N = 12); and amyloid positive at both time points (square, N = 9). Amyloid rate of change is follow-up Centiloid minus baseline Centiloid, divided by the time interval (years). Participants are coloured based on APOE4 genotype (ε2ε3 N = 7; ε2ε4 N = 2; ε3ε3 N = 42; ε3ε4 N = 37; ε4ε4 N = 2; outlier is ε2ε4)

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