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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice

Fig. 5

Unaltered distribution of GIRK3 in CA1 pyramidal cells of APP/PS1 mice. Electron micrographs showing immunoparticles for GIRK3 in the stratum radiatum of the hippocampal CA1 field at 12 months of age, as detected using the SDS-FRL technique in wild type and APP/PS1 mice. AE Both in wild type and APP/PS1, immunoparticles for GIRK3 were detected mostly scattered (black arrows), or less frequently forming clusters (black circles), in dendritic spines (s) and oblique dendrites (oDen) of CA1 pyramidal cells, as well as presynaptically along the extrasynaptic site and active zone (az, pink overlay) of axon terminals (at). F Quantitative analysis showing that the density of GIRK3 immunoparticles was unaltered in wild type and APP/PS1 mice in the post- and presynaptic subcellular compartments analysed (Mann–Whitney test, p = 0.14 for spines, p = 0.35 for dendritic spines, p = 0.064 for extrasynaptic sites, p = 0.369 for active zone sites). Error bars indicate SEM. Scale bars: AF, 0.2 μm

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