Fig. 5

Temporal evolution of assessed cerebral perfusion measures stratified by limbic versus cortical regions of interest. Cumulative summary of DSC-MRI perfusion parameter analysis is shown for A relative cerebral blood flow (rCBF), B relative cerebral blood volume (rCBV), and C relative mean transit time (rMTT). There was a significant increase (mixed ANOVA effect) in limbic rCBF (4–16 weeks), cortical rCBF (8 weeks), limbic and cortical rCBV (8 weeks), and cortical rMTT (4 weeks) relative to baseline in subjects with cognitive improvement (group 1). There were no significant differences in the cerebral perfusion measures in subjects with stable (group 2) and worsened (group 3) cognition as assessed in the limbic and cortical regions. Data are mean ± standard error mean (SEM). *P<0.05, **P<0.01 versus baseline