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Table 1 Patient characteristics

From: A longitudinal study on quality of life along the spectrum of Alzheimer’s disease

Baseline characteristics SCD MCI Dementia Amyloid-positive
SCD, MCI, dementiaa
Amyloid- positive (n = 105) Amyloid-negative (n = 342) p-value Amyloid- positive (n = 144) Amyloid- negative (n = 132) p-value Amyloid- positive (n = 417) p-value
Age, mean years (SD) 64.6 (6.6) 60.7 (6.2) < 0.001* 65.9 (6.6) 63.3 (7.3) 0.002* 64.4 (7.0) 0.08
Female, n (%) 50 (47) 129 (38) 0.07 65 (45) 25 (19) < 0.001* 213 (51) 0.44
Education Verhage, mean (SD) 5.6 (1.2) 5.5 (1.1) 0.38 5.4 (1.3) 5.1 (1.2) 0.06 5.1 (1.2) < 0.001*
MMSE, median (IQR) 28 (27–29) 29 (27–30) 0.02* 27 (25–28) 27 (26–28) 0.24 23 (19–25) < 0.001*
CCI, mean (SD) 2.4 (1.1) 2.1 (1.2) 0.05 2.7 (1.2) 2.8 (1.7) 0.64 3.4 (1.2) < 0.001*
GDS, median (IQR) 2 (1–4) 2 (1–4) 0.59 2 (1–4) 3 (2–6) 0.001* 2 (1–4) 0.82
RAVLT
Immediate recall, mean (SD)
41.9 (8.3) 42.3 (9.3) 0.67 31.0 (7.2) 31.5 (7.8) 0.60 23.3 (8.8) < 0.001*
RAVLT
Delayed recall, mean (SD)
8.1 (3.0) 8.6 (3.0) 0.16 3.4 (2.5) 4.4 (2.7) 0.001* 2.1 (2.6) < 0.001*
  1. *Statistically significant based on p < 0.05
  2. aSee Additional file 1 for post hoc analysis
  3. SCD subjective cognitive decline, MCI mild cognitive impairment, MMSE mini-mental state examination, CCI Charlson Comorbidity Index, GDS Geriatric Depression Scale, RAVLT Rey-Auditory Verbal Learning
  4. P-values were obtained using independent samples t-tests or ANOVA for normally distributed continuous variables (mean (SD)), Mann-Whitney two samples tests for non-normally distributed continuous variables (median (IQR)), and chi-square tests for categorical variables (n(%))