Table 1 Sample demographics, mean (SD)

ADNI

CN Ab-/Tau-

(n=199)

CN Ab+

(n=119)

MCI Ab+

(n=97)

AD dementia

(n=59)

p-value

Age, years

70.88 (6.40)^†,‡,§

74.64 (7.39)^*

74.77 (7.40)^*

76.20 (9.33)^*

<0.001

Sex, M/F

72 / 127

44 / 75

51 / 46

31 / 28

0.011

Education, years

16.78 (2.28)^§

16.68 (2.38)^§

16.11 (2.46)

15.44 (2.41)^*,†

<0.001

MMSE

29.19 (1.07)^‡,§

28.91 (1.36)^‡,§

27.49 (2.19)^*,†,§

22.19 (3.96)^*,†,‡

<0.001

APOE e4 carriers -/+^a

136- / 51+^†,‡,§

54- / 60+^*

29- / 53+^*

18- / 32+^*

<0.001

Mean tau-PET follow-up, years^b

1.72 (0.53)

1.64 (0.57)

1.45 (0.71)

1.37 (0.49)

0.299

BioFINDER-1

CN Ab-/Tau-

(n=36)

CN Ab+

(n=30)

MCI Ab+

(n=26)

AD dementia

(n=46)

p-value

Age, years

73.86 (7.27)

73.80 (7.44)

71.73 (9.72)

71.43 (7.34)

0.274

Sex, M/F

19 / 17

12 / 18

18 / 8

25 / 21

0.187

Education, years

12.42 (3.80)

11.93 (3.72)

12.21 (3.93)

12.22 (3.75)

0.928

MMSE

28.86 (1.10)^‡,§

28.83 (1.15)^‡,§

25.58 (3.06)^*,†,§

20.96 (4.87)^*,†,‡

< 0.001

APOE e4 carriers -/+

29- / 7+^†,‡,§

8- / 22+^*

6- / 20+^*

19- / 27+^*

< 0.001

Mean tau-PET follow-up, years^c

2.03 (0.47)

1.94 (0.32)

1.82 (0.12)

1.87 (0.34)

0.470