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Table 2 Aβ isoform levels and Aβ42/40 ratios measured on Elecsys without or with pre-analytical immunoprecipitation

From: Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation

 

Aβ40 (plasma)

Aβ40 (IP-eluate)

Aβ42 (plasma)

Aβ42 (IP-eluate)

Aβ42/40 (plasma)

Aβ42/40 (IP-eluate)

P-value1

0.3906

0.5555

0.003

<0.0001

0.0003

<0.0001

Median of Aβ+

322.8

171.5

26.5

16.6

0.078

0.098

MAD of Aβ+

43.6

26.5

6.6

2.8

0.017

0.006

Median of Aβ−

326.7

174.3

30.4

19.8

0.093

0.116

MAD of Aβ−

45.3

27.1

6.4

4.2

0.013

0.010

  1. 1Mann-Whitney-test p-values for the comparison between the groups Aβ-positive (Aβ+) and Aβ-negative (Aβ−)
  2. Aβ amyloid-β, Aβ+ Aβ-positive: CSF Aβ42/40 ≤ 0.050, Aβ− Aβ-negative: CSF Aβ42/40 > 0.050, MAD median absolute deviation with scaling factor 1.4286
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Alzheimer's Research & Therapy

ISSN: 1758-9193