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Table 4 Associations between change in amyloid burden and cognitive test performance

From: Longitudinal change in ATN biomarkers in cognitively normal individuals

  Baseline Longitudinal
Positive-negative Negative-positive Positive-positive Positive-negative Negative-positive Positive-positive
VAT-A 0.20 (0.30) 0.16 (0.21) 0.05 (0.16) 0.01 (0.11) 0.03 (0.05) 0.01 (0.04)
RAVLT immediate 3.24 (3.36) 0.65 (2.40) − 2.28 (1.88) − 0.11 (0.88) 0.04 (0.36) − 1.40 (0.32)*
RAVLT delayed 0.88 (1.18) 0.55 (0.85) − 0.96 (0.66) − 0.03 (0.30) 0.05 (0.12) − 0.51 (0.10)*
Animal fluency 3.48 (2.13) 1.42 (1.51) 0.79 (1.18) 0.71 (0.57) − 0.05 (0.23) − 0.23 (0.21)
TMT-A 0.01 (0.11) 0.13 (0.08) 0.05 (0.06) 0.03 (0.04) − 0.04 (0.02) − 0.01 (0.02)
TMT-B 0.04 (0.13) 0.10 (0.10) − 0.07 (0.08) 0.01 (0.03) − 0.02 (0.01) − 0.02 (0.01)*
Stroop I 0.05 (0.07) 0.06 (0.05) 0.01 (0.04) 0.01 (0.02) − 0.03 (0.01)* − 0.01 (0.01)
Stroop II 0.06 (0.07) 0.00 (0.05) 0.04 (0.04) 0.00 (0.02) − 0.02 (0.01) − 0.02 (0.01)
Stroop III 0.12 (0.09) 0.01 (0.06) 0.02 (0.05) − 0.01 (0.02) − 0.03 (0.01)* − 0.02 (0.01)*
MMSE − 0.23 (0.48) 0.06 (0.34) − 0.29 (0.26) − 0.14 (0.18) 0.01 (0.11) − 0.06 (0.08)
  1. Data is presented as beta (SE) as estimated by linear mixed models. Models included a four level variable indicating change in amyloid status (negative-negative (reference), negative-positive, positive-negative and positive-positive), time, and their interaction as predictors. All models were adjusted for age, sex, and education. Outcome was cognitive test performance. Baseline estimates represent the association between the predictor and baseline test performance; longitudinal estimates represent the association of the interaction between predictor and time and reflect the slope of cognitive test performance. VAT visual association test, RAVLT Rey auditory verbal learning task, TMT trail making test, MMSE mini mental state examination. *p < 0.05