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Table 1 Baseline demographics

From: Longitudinal change in ATN biomarkers in cognitively normal individuals

  n Total (n = 92) Baseline amyloid negative (n = 68) Baseline amyloid positive (n = 24)
Agea 92 65.29 ± 8.02 64.82 ± 7.81 66.61 ± 8.61
Sex, n female (%)b 92 39 (42%) 29 (43%) 10 (42%)
Education, median [IQR]c 92 6 [5–6] 6 [5–6] 6 [5–7]
APOE ε4 carriers, n (%)b 87 27 (31%) 14 (21%) 13 (62%)*
[18F]florbetapir BPNDc 92 0.16 ± 0.12 0.11 ± 0.05 0.30 ± 0.16*
[18F]flortaucipir BPNDc 44 0.01 ± 0.08 − 0.01 ± 0.05 0.05 ± 0.11*
MTA scorec 92 0.25 [0–1] 0.50 [0–1] 0.00 [0–1]
Fazekasc 91 0.96 ± 0.82 0.96 ± 0.84 0.96 ± 0.75
Microbleeds, n (%)b 92 21 (23%) 15 (22%) 6 (25%)
VAT-Ac 92 11.61 ± 0.94 11.62 ± 0.98 11.58 ± 0.83
RAVLT immediatea 92 44.64 ± 7.68 44.76 ± 7.07 44.29 ± 9.37
RAVLT delayeda 92 9.00 ± 3.26 9.34 ± 3.02 8.03 ± 3.75
Animal fluencyc 92 24.30 ± 6.22 24.09 ± 6.16 24.92 ± 6.49
TMT-Ac 92 34.89 ± 11.85 34.43 ± 12.11 36.21 ± 11.24
TMT-Bc 92 81.03 ± 40.55 80.93 ± 44.89 81.33 ± 25.21
Stroop Ic 91 43.85 ± 9.06 44.18 ± 10.12 42.92 ± 5.13
Stroop IIc 90 59.48 ± 11.64 60.13 ± 12.49 57.57 ± 8.68
Stroop IIIc 90 94.64 ± 22.33 95.61 ± 22.91 91.83 ± 20.79
MMSEc 92 28.86 ± 1.14 28.93 ± 1.15 28.67 ± 1.13
  1. Baseline demographics for the total sample and for amyloid negative and positive individuals separately. Data is presented as mean ± SD unless otherwise specified. Baseline amyloid status is determined by visual read of [18F]florbetapir PET. [18F]florbetapir BPND is calculated in a composite ROI. [18F]flortaucipir BPND is calculated in lateral temporal gyrus. MTA score is calculated by averaging right and left sides. Number of microbleeds is dichotomized into 0 counts and ≥ 1 counts; n shown is the number of participants with ≥ 1 count. Neuropsychological test scores shown represent baseline values at the visit closest to the baseline [18F]florbetapir scan
  2. BPND binding potential, MTA medial temporal atrophy, VAT visual association test, RAVLT Rey auditory verbal learning task, TMT trail making test, MMSE mini mental state examination. at-test; bchi-square test; cMann-Whitney U test. *p < 0.05