Skip to main content

Table 1 Baseline demographics

From: Longitudinal change in ATN biomarkers in cognitively normal individuals

 

n

Total (n = 92)

Baseline amyloid negative (n = 68)

Baseline amyloid positive (n = 24)

Agea

92

65.29 ± 8.02

64.82 ± 7.81

66.61 ± 8.61

Sex, n female (%)b

92

39 (42%)

29 (43%)

10 (42%)

Education, median [IQR]c

92

6 [5–6]

6 [5–6]

6 [5–7]

APOE ε4 carriers, n (%)b

87

27 (31%)

14 (21%)

13 (62%)*

[18F]florbetapir BPNDc

92

0.16 ± 0.12

0.11 ± 0.05

0.30 ± 0.16*

[18F]flortaucipir BPNDc

44

0.01 ± 0.08

− 0.01 ± 0.05

0.05 ± 0.11*

MTA scorec

92

0.25 [0–1]

0.50 [0–1]

0.00 [0–1]

Fazekasc

91

0.96 ± 0.82

0.96 ± 0.84

0.96 ± 0.75

Microbleeds, n (%)b

92

21 (23%)

15 (22%)

6 (25%)

VAT-Ac

92

11.61 ± 0.94

11.62 ± 0.98

11.58 ± 0.83

RAVLT immediatea

92

44.64 ± 7.68

44.76 ± 7.07

44.29 ± 9.37

RAVLT delayeda

92

9.00 ± 3.26

9.34 ± 3.02

8.03 ± 3.75

Animal fluencyc

92

24.30 ± 6.22

24.09 ± 6.16

24.92 ± 6.49

TMT-Ac

92

34.89 ± 11.85

34.43 ± 12.11

36.21 ± 11.24

TMT-Bc

92

81.03 ± 40.55

80.93 ± 44.89

81.33 ± 25.21

Stroop Ic

91

43.85 ± 9.06

44.18 ± 10.12

42.92 ± 5.13

Stroop IIc

90

59.48 ± 11.64

60.13 ± 12.49

57.57 ± 8.68

Stroop IIIc

90

94.64 ± 22.33

95.61 ± 22.91

91.83 ± 20.79

MMSEc

92

28.86 ± 1.14

28.93 ± 1.15

28.67 ± 1.13

  1. Baseline demographics for the total sample and for amyloid negative and positive individuals separately. Data is presented as mean ± SD unless otherwise specified. Baseline amyloid status is determined by visual read of [18F]florbetapir PET. [18F]florbetapir BPND is calculated in a composite ROI. [18F]flortaucipir BPND is calculated in lateral temporal gyrus. MTA score is calculated by averaging right and left sides. Number of microbleeds is dichotomized into 0 counts and ≥ 1 counts; n shown is the number of participants with ≥ 1 count. Neuropsychological test scores shown represent baseline values at the visit closest to the baseline [18F]florbetapir scan
  2. BPND binding potential, MTA medial temporal atrophy, VAT visual association test, RAVLT Rey auditory verbal learning task, TMT trail making test, MMSE mini mental state examination. at-test; bchi-square test; cMann-Whitney U test. *p < 0.05