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Table 4 Associations of significantly associated Olink Biomarker levels with vascular dementia incidence. For associations of not significantly associated biomarkers, see Supplemental Table 8

From: Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study

Olink Biomarker

Value of 1 SD

Vascular dementia (n=195 cases)

OR (95% CI) per 1 SD*

p-value per 1 SD

FDR corrected p-value†

CCL11

0.697

1.30 (1.09-1.56)

0.0042

0.0137

CCL23

0.732

1.24 (1.04-1.48)

0.0148

0.0347

CD5

0.523

1.32 (1.11-1.56)

0.0016

0.0091

CD244

0.587

1.39 (1.16-1.66)

0.0004

0.0072

CDCP1

0.894

1.25 (1.05-1.48)

0.0122

0.0313

CX3CL1

0.669

1.35 (1.13-1.61)

0.0011

0.0072

CXCL1

0.901

1.22 (1.04-1.43)

0.0151

0.0347

CXCL5

0.957

1.39 (1.16-1.67)

0.0004

0.0072

CXCL6

0.848

1.32 (1.11-1.57)

0.0018

0.0091

CXCL9

0.953

1.25 (1.06-1.47)

0.0089

0.0256

CXCL10

0.953

1.28 (1.09-1.50)

0.0029

0.0116

DNER

0.488

1.37 (1.13-1.65)

0.0010

0.0072

EN-RAGE

1.307

1.41 (1.18-1.68)

0.0001

0.0036

Flt3L

0.629

1.22 (1.03-1.45)

0.0226

0.0493

HGF

0.719

1.32 (1.11-1.58)

0.0019

0.0091

IL-7

0.798

1.24 (1.05-1.47)

0.0107

0.0296

IL-10

0.863

1.27 (1.09-1.48)

0.0017

0.0091

IL-18

0.763

1.36 (1.14-1.63)

0.0006

0.0072

IL-18R1

0.602

1.30 (1.09-1.55)

0.0034

0.0122

LAP TGF-beta-1

0.574

1.33 (1.12-1.57)

0.0011

0.0072

LIF-R

0.503

1.36 (1.14-1.63)

0.0007

0.0072

MCP-2

0.769

1.24 (1.04-1.47)

0.0154

0.0347

MCP-4

0.927

1.26 (1.05-1.51)

0.0114

0.0304

MMP-10

0.761

1.30 (1.10-1.54)

0.0022

0.0099

NT-3

0.544

1.26 (1.08-1.46)

0.0025

0.0106

OPG

0.609

1.38 (1.15-1.67)

0.0007

0.0072

PD-L1

0.600

1.26 (1.07-1.49)

0.0056

0.0175

TGF-alpha

0.829

1.23 (1.05-1.46)

0.0126

0.0313

TNFRSF9

0.636

1.26 (1.06-1.49)

0.0073

0.0219

TRAIL

0.513

1.32 (1.09-1.59)

0.0037

0.0127

TWEAK

0.647

1.36 (1.13-1.63)

0.0010

0.0072

VEGF-A

0.794

1.43 (1.20-1.70)

0.0001

0.0036

uPA

0.604

1.30 (1.09-1.55)

0.0034

0.0122

  1. Abbreviations: SD standard deviation, CI confidence interval, FDR false discovery rate; For biomarker abbreviations, see Supplemental Table 1
  2. All associations between Olink Biomarkers and the dementia outcome in this table are statistically significant after correction for multiple testing (FDR corrected p < 0.05). The line for the most important biomarker, VEGF-A, which is also independently from other Olink biomarkers associated with the dementia outcome, is printed in bold. However, please note that this table shows its association with the outcome when the biomarker is put singularly in the multivariate logistic regression model
  3. * Multivariate logistic regression model adjusted for age (continuously), sex, education, physical activity, BMI (categorical), CVD, diabetes, depression, APOE genotype
  4. † P-values corrected for multiple testing by the Benjamini and Hochberg method
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Alzheimer's Research & Therapy

ISSN: 1758-9193