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Table 3 Associations of significantly associated Olink Biomarker levels with Alzheimer’s disease incidence. For associations of not significantly associated biomarkers, see Supplemental Table 7

From: Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study

Olink Biomarker

Value of 1 SD

Alzheimer’s disease (n=163 cases)

OR (95% CI)

per 1 SD*

p-value

per 1 SD

FDR corrected

p-value

CASP-8

1.364

1.31 (1.10-1.57)

0.0025

0.0156

CCL23

0.732

1.43 (1.17-1.75)

0.0004

0.0086

CCL28

0.548

1.36 (1.14-1.61)

0.0005

0.0086

CD6

0.757

1.30 (1.08-1.58)

0.0067

0.0254

CD244

0.587

1.39 (1.14-1.70)

0.0010

0.0120

CX3CL1

0.669

1.35 (1.10-1.65)

0.0034

0.0175

CXCL5

0.957

1.37 (1.12-1.68)

0.0023

0.0156

CXCL6

0.848

1.34 (1.11-1.62)

0.0026

0.0156

DNER

0.488

1.37 (1.12-1.68)

0.0025

0.0156

EN-RAGE

1.307

1.51 (1.25-1.83)

<0.0001

0.0036

HGF

0.719

1.36 (1.12-1.66)

0.0017

0.0153

IL-10RB

0.533

1.33 (1.08-1.63)

0.0066

0.0254

LAP TGF-beta-1

0.574

1.46 (1.21-1.76)

0.0001

0.0036

LIF-R

0.503

1.31 (1.08-1.60)

0.0062

0.0254

PD-L1

0.600

1.31 (1.09-1.57)

0.0034

0.0175

ST1A1

1.304

1.30 (1.08-1.57)

0.0062

0.0254

STAMBP

0.833

1.26 (1.06-1.51)

0.0108

0.0370

TGF-alpha

0.829

1.26 (1.05-1.52)

0.0140

0.0458

TRAIL

0.513

1.30 (1.06-1.59)

0.0104

0.0370

TWEAK

0.647

1.38 (1.13-1.69)

0.0016

0.0153

VEGF-A

0.794

1.32 (1.09-1.60)

0.0042

0.0202

uPA

0.604

1.40 (1.16-1.71)

0.0006

0.0086

  1. Abbreviations: SD standard deviation, CI confidence interval, FDR false discovery rate; For biomarker abbreviations, see Supplemental Table 1
  2. All associations between Olink Biomarkers and the dementia outcome in this table are statistically significant after correction for multiple testing (FDR corrected p < 0.05). The lines for the most important biomarkers, EN-RAGE and LAP TGF-beta-1, which were also independently from other Olink biomarkers associated with the dementia outcome, are printed in bold. However, please note that this table shows their association with the outcome when they are put singularly in the multivariate logistic regression model
  3. * Multivariate logistic regression model adjusted for age (continuously), sex, education, physical activity, BMI (categorical), CVD, diabetes, depression, APOE genotype
  4. P-values corrected for multiple testing by the Benjamini and Hochberg method