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Table 5 Correlations between the hippocampal IgA area fraction and IgA-positive cell number and neuropathology in cohort II

From: Increased plasma and brain immunoglobulin A in Alzheimer’s disease is lost in apolipoprotein E ε4 carriers

 

Neuropathology (score)

All groups

NC

AD

APOEε4

+APOEε4

IgA area fraction (%)

0.489*

ns

ns

0.836***

ns

LB

ns

ns

ns

0.735*

ns

NFT

ns

ns

ns

0.855***

ns

IgA+ cells (no.)

0.502*

ns

ns

0.862***

ns

LB

ns

0.820*

ns

0.660*

ns

NFT

0.506*

ns

ns

0.844***

ns

  1. Data were analysed using Spearman’s correlation test
  2. amyloid beta, AD Alzheimer’s disease, APOE4 apolipoprotein 4, −APOEε4 APOEε4 non-carrier, +APOEε4 APOEε4 carrier, IgA immunoglobulin A, IgA+ immunoglobulin A-positive, LB Lewy body, NC non-demented control, NFT neurofibrillary tangle, no. number, ns not significant
  3. *Significant correlation at p ≤ 0.05 level
  4. **Significant correlation at p ≤ 0.01 level
  5. ***Significant correlation at p ≤ 0.001 level