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Table 1 Demographic and clinical characteristics of the study population

From: Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease

Variable

YCU

OCU

EOCI

LOCI

n

30

44

15

53

Age (years)

58.3 ± 5.5

72.8 ± 6.2b

62.8 ± 6.0a

76.4 ± 5.3ab

Age at onset (years)

n. a.

n. a.

59.4 ± 5.6

73.6 ± 5.3b

Females,n(%)

19 (63.3)

26 (59.1)

10 (66.7)

33 (62.3)

Education (years)

13.3 ± 3.9

11.6 ± 4.7

11.6 ± 5.0

10.5 ± 5.1

MMSE

28.9 ± 1.5

27.8 ± 1.8b

21.5 ± 6.2a

22.8 ± 4.2a

CDR-SB

0.0 ± 0.0

0.0 ± 0.0

3.3 ± 2.3a

2.9 ± 1.8a

APOEε4 carrier,n(%)

5 (16.7)

8 (18.2)

10 (66.7)a

26 (49.1)a

Amyloid positivity,n(%)

1 (3.3)

6 (13.6)

15 (100)a

53 (100)a

Follow-up interval (months)

26.0 ± 3.6

25.1 ± 3.6

23.4 ± 1.5a

23.0 ± 1.4a

  1. Data are presented as mean ± standard deviation. Significant between-group-differences are marked with “a” for YCU vs. EOCI and OCU vs. LOCI, and “b” for YCU vs. OCU and EOCI vs. LOCI
  2. Abbreviations: YCU/OCU young and old cognitively unimpaired, EOCI/LOCI cognitively impaired due to early- and late-onset Alzheimer’s disease, MMSE mini-mental state examination, CDR-SB clinical dementia rating sum-of-boxes