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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease

Fig. 5

Intracommunity tau-providing hubs determined in each sliding window. The entire tau-providing hubs identified across whole sliding windows were exclusive between the corresponding communities in both YCU/EOCI and OCU/LOCI groups (left). The characteristics of the selected hubs were investigated based on where the hub is defined across the windows and how many regions the hub influences (right). The x axes of the color-coded matrix represent each sliding window and the y axes represent regions selected as hubs. Colors for the matrices represent the out-degrees, normalized by the maximum number of regions comprising each community. The black dots represent the location in which each region was qualified as hub and the black tick marks represent the boundaries of each segment. Abbreviations: YCU and OCU, young and old cognitively unimpaired; EOCI and LOCI, cognitively impaired due to early- and late-onset Alzheimer’s disease. Abbreviations for the region labels are described in the legend of Fig. 3

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Alzheimer's Research & Therapy

ISSN: 1758-9193