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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Dynamic network model reveals distinct tau spreading patterns in early- and late-onset Alzheimer disease

Fig. 4

Dynamic community structures in a tau spreading network. Three major communities were found in the latter part of the sliding windows in YCU/EOCI group (upper) and four were found in the OCU/LOCI group (lower), which have distinct changing patterns in the number of overall spreading pathways. For each community, an example map and spreading directions for a specific window are presented in an inset based on the community assignment of that window. The x-axes represent each sliding window and the y axes represent total intracommunity edges normalized by the maximum number of regions comprising each community across sliding windows. The yellow circles indicate tau-providing hubs within the corresponding community and the red wedges indicate the boundaries of each segment. Abbreviations: YCU and OCU, young and old cognitively unimpaired; EOCI and LOCI, cognitively impaired due to early- and late-onset Alzheimer’s disease. Abbreviations for the region labels are described in the legend of Fig. 3

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