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Table 1 Baseline demographic and clinical characteristics of the SMC and Obj-SCD groups

From: Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint

 

Total sample

SMC−

SMC+

F or χ2

p

Obj-SCD−

Obj-SCD+

F or χ2

p

N

236

77

159

  

173

63

  

Age, mean (SD)

70.82 (6.24)

70.00 (5.59)

71.21 (6.52)

F = 1.96

0.162

70.80 (6.45)

70.88 (5.70)

F = 0.09

0.926

Education, mean (SD)

16.86 (2.21)

17.09 (2.10)

16.74 (2.25)

F = 1.30

0.256

16.81 (2.15)

16.98 (2.37)

F = 0.29

0.591

Female/woman, %

57.2%

59.7%

56.0%

χ2= 0.30

0.584

59.5%

50.8%

χ2= 1.44

0.230

Race, %

   

χ2 = 6.32

0.176

  

χ2= 2.75

0.600

 American Indian/Alaska Native

0.4%

1.3%

0.0%

  

0.6%

0.0%

  

 Asian

1.7%

1.3%

1.9%

  

1.2%

3.2%

  

 Black

3.0%

1.3%

3.8%

  

2.3%

4.8%

  

 White

92.4%

96.1%

90.6%

  

93.1%

90.5%

  

 More than one

2.5%

0.0%

3.8%

  

2.9%

1.6%

  

Ethnicity, %

   

χ2 = 2.98

0.225

  

χ2= 2.24

0.326

 Hispanic/Latino

2.1%

0.0%

3.1%

  

2.9%

0.0%

  

 Non-Hispanic/non-Latino

97.5%

100%

96.2%

  

96.5%

100%

  

 Unknown

0.4%

0.0%

0.6%

  

0.6%

0.0%

  

Pulse pressure, mean (SD)

55.40 (15.76)

57.09 (15.06)

54.58 (16.07)

F = 1.31

0.253

55.43 (15.20)

55.33 (17.35)

F = .002

0.968

APOE ε4 carrier, %

36.0%

29.9%

39.0%

χ2 = 1.87

0.171

37.0%

33.3%

χ2 = 0.27

0.604

GDS, mean (SD)

0.76 (1.11)

0.40 (0.67)

0.93 (1.24)

F = 12.24

< 0.001

0.71 (1.05)

0.89 (1.27)

F = 1.18

0.278

CCI, mean (SD)

19.65 (7.14)

13.56 (1.23)

22.60 (6.94)

F = 128.39

< 0.001

19.12 (6.63)

21.11 (8.24)

F = 3.65

0.057

PACC, mean (SD)

0.17 (2.82)

0.85 (2.69)

− 0.15 (2.83)

F = 6.67

0.010

0.75 (2.36)

− 1.40 (3.35)

F = 30.20

< 0.001

Tau PET, mean (SD)

1.43 (0.15)

1.44 (0.18)

1.43 (0.13)

F = 0.17

0.681

1.42 (0.13)

1.47 (0.19)

F = 4.03

0.046

Aβ PETa, mean (SD)

21.93 (30.46)

19.20 (28.26)

23.26 (31.49)

F = 0.92

0.340

21.69 (30.06)

22.58 (31.81)

F = 0.30

0.585

Aβ PET positivity, %

34.5%

29.9%

36.7%

F = 1.07

0.301

34.1%

35.5%

χ2= 0.04

0.844

  1. SMC subjective memory complaint, Obj-SCD objective subtle cognitive decline, APOE apolipoprotein E, GDS Geriatric Depression Scale, CCI Cognitive Change Index, PACC Modified Preclinical Alzheimer Cognitive Composite, Tau PET Braak III/IV SUVR, Aβ PET β-amyloid cortical SUVR in centiloids, F statistic reported for one-way ANOVAs, χ2 statistic report for chi-square tests
  2. a1 SMC+/Obj-SCD+ participant is missing Aβ PET data