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Table 1 Baseline demographic and clinical characteristics of the SMC and Obj-SCD groups

From: Tau levels are higher in objective subtle cognitive decline but not subjective memory complaint

  Total sample SMC− SMC+ F or χ2 p Obj-SCD− Obj-SCD+ F or χ2 p
N 236 77 159    173 63   
Age, mean (SD) 70.82 (6.24) 70.00 (5.59) 71.21 (6.52) F = 1.96 0.162 70.80 (6.45) 70.88 (5.70) F = 0.09 0.926
Education, mean (SD) 16.86 (2.21) 17.09 (2.10) 16.74 (2.25) F = 1.30 0.256 16.81 (2.15) 16.98 (2.37) F = 0.29 0.591
Female/woman, % 57.2% 59.7% 56.0% χ2= 0.30 0.584 59.5% 50.8% χ2= 1.44 0.230
Race, %     χ2 = 6.32 0.176    χ2= 2.75 0.600
 American Indian/Alaska Native 0.4% 1.3% 0.0%    0.6% 0.0%   
 Asian 1.7% 1.3% 1.9%    1.2% 3.2%   
 Black 3.0% 1.3% 3.8%    2.3% 4.8%   
 White 92.4% 96.1% 90.6%    93.1% 90.5%   
 More than one 2.5% 0.0% 3.8%    2.9% 1.6%   
Ethnicity, %     χ2 = 2.98 0.225    χ2= 2.24 0.326
 Hispanic/Latino 2.1% 0.0% 3.1%    2.9% 0.0%   
 Non-Hispanic/non-Latino 97.5% 100% 96.2%    96.5% 100%   
 Unknown 0.4% 0.0% 0.6%    0.6% 0.0%   
Pulse pressure, mean (SD) 55.40 (15.76) 57.09 (15.06) 54.58 (16.07) F = 1.31 0.253 55.43 (15.20) 55.33 (17.35) F = .002 0.968
APOE ε4 carrier, % 36.0% 29.9% 39.0% χ2 = 1.87 0.171 37.0% 33.3% χ2 = 0.27 0.604
GDS, mean (SD) 0.76 (1.11) 0.40 (0.67) 0.93 (1.24) F = 12.24 < 0.001 0.71 (1.05) 0.89 (1.27) F = 1.18 0.278
CCI, mean (SD) 19.65 (7.14) 13.56 (1.23) 22.60 (6.94) F = 128.39 < 0.001 19.12 (6.63) 21.11 (8.24) F = 3.65 0.057
PACC, mean (SD) 0.17 (2.82) 0.85 (2.69) − 0.15 (2.83) F = 6.67 0.010 0.75 (2.36) − 1.40 (3.35) F = 30.20 < 0.001
Tau PET, mean (SD) 1.43 (0.15) 1.44 (0.18) 1.43 (0.13) F = 0.17 0.681 1.42 (0.13) 1.47 (0.19) F = 4.03 0.046
Aβ PETa, mean (SD) 21.93 (30.46) 19.20 (28.26) 23.26 (31.49) F = 0.92 0.340 21.69 (30.06) 22.58 (31.81) F = 0.30 0.585
Aβ PET positivity, % 34.5% 29.9% 36.7% F = 1.07 0.301 34.1% 35.5% χ2= 0.04 0.844
  1. SMC subjective memory complaint, Obj-SCD objective subtle cognitive decline, APOE apolipoprotein E, GDS Geriatric Depression Scale, CCI Cognitive Change Index, PACC Modified Preclinical Alzheimer Cognitive Composite, Tau PET Braak III/IV SUVR, Aβ PET β-amyloid cortical SUVR in centiloids, F statistic reported for one-way ANOVAs, χ2 statistic report for chi-square tests
  2. a1 SMC+/Obj-SCD+ participant is missing Aβ PET data