Fig. 2

Estimated change in cognitive composite scores for each trial arm. The graphs visualize the trajectories modeled using the PP linear time LMMs. The cognitive retest effect parameters were omitted from the graphed models, as these resulted in discontinuous trajectories. The time-by-arm interaction was not significant for any composite (ps > 0.29), although PACC5_Abridged scores increased in both arms during the trial (p < 0.001). In order to aid interpretability, the graphed data are for a “prototypical” female participant with sample grand mean values for age, education, state anxiety, and depressive symptoms, at the Barcelona site. Shaded areas are 95% confidence intervals for the fixed effects. Abbreviations: PACC5_Abridged, Abridged Preclinical Alzheimer Cognitive Composite 5; CMBAS, Caring Mindfulness-Based Approach for Seniors; HSMP, Health Self-Management Program; LMM, linear mixed model; PP, per-protocol