Fig. 2

Identification of DIAD variants in densely affected Alzheimer’s disease (AD) pedigrees. Individuals with MCI and dementia have been classified as symptomatic and are represented with shaded rhombus. All generations under the family average age at onset were excluded, and gender has been masked to maintain anonymity. Diagonal lines represent deceased individuals. All symptomatic participants in the study were labeled with symptomatic age at onset. If the age at onset was unknown, the data were labeled as not available (Unk). Arrows indicate the index case. (+) indicate those individuals with DNA, all of whom are mutation/variant carriers. (−) indicate those individuals with DNA, all of whom are NOT mutation/variant carriers. For asymptomatic mutation carriers under the family age, the results of genetic testing were excluded to prevent potential disclosure of mutation status