Skip to main content
Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Fig. 5

Knockdown of BACE1 blocks KLF5-induced amyloidogenic APP processing in HT22 cells. A Representative Western blots and relative quantification of BACE1 protein in HT22 cells co-transfected with BACE1-shRNA or control-shRNA and KLF5 or the control vector. B BACE1 activity (fluorogenic BACE1 activity assay) in HT22 cells co-transfected with BACE1-shRNA or control-shRNA and KLF5 or the control vector. C Representative Western blots and relative quantification of APP-CTFβ protein in HT22 cells co-transfected with BACE1-shRNA or control-shRNA and KLF5 or the control vector. D Levels of Aβ40, Aβ42, and sAPPβ in the medium of HT22 cells co-transfected with BACE1-shRNA or control-shRNA and KLF5 or control vector. Data are mean ± s.e.m of three separate experiments (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001; one-way ANOVA)

Back to article page